Mathematical Modeling of 177Lu-DOTATATE for Neuroendocrine Tumor Treatment

Sowwanee Jitsinchayakul, Usa Humphries, Teerapol Saleewong, Kitiwat Khamwan

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  • Support Team

Keywords:

177Lu-DOTATATE, mathematical model of 177Lu-DOTATATE for neuroendocrine tumor treatment, neuroendocrine tumor

Abstract

Nowadays, cancer treatment with radiopharmaceuticals is an alternative option for patients who do not respond to treatment with other methods, such as surgical treatment, chemotherapy, or external beam radiotherapy. The 177Lu-DOTATATE is a type of theranostic radiopharmaceutical used to treat neuroendocrine tumor (NETs) patients. This research's objectives were to develop a mathematical model for treating NETS patients with 177Lu-DOTATATE and estimate the appropriate parameters of the model to determine the changes of 177Lu-DOTATATE in the patient's body. The 177Lu-DOTATATE can deliver into cancer cells and organs throughout the body, considered two models, Model I and Model II. They have a similar dynamical compartment structure, but the 177Lu-DOTATATE eliminated from the tumor is different between the two models. This research considers the appropriate parameters for each model to find the solution of the system of ordinary differential equations of each model according to the 4th Runge-Kutta method. The results of Model I and II tend to change 177Lu-DOTATATE in tumors and organs according to the results obtained in mice. After a mathematical model for rearing NETs patients with 177Lu-DOTATATE was developed, it will help the physicians to analyze as the guidelines for treating NETs patients, which is more effective.

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Published

2022-12-01

How to Cite

Team, S. (2022). Mathematical Modeling of 177Lu-DOTATATE for Neuroendocrine Tumor Treatment: Sowwanee Jitsinchayakul, Usa Humphries, Teerapol Saleewong, Kitiwat Khamwan. Thai Journal of Mathematics, 20(4), 1621–1639. Retrieved from https://thaijmath2.in.cmu.ac.th/index.php/thaijmath/article/view/1426

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